Clinical Efficacy of High-Frequency Ultrasound in Differentiating the Nature of Thyroid Nodules

The Objective is to investigate the diagnostic efficacy of high-frequency ultrasound in differentiating benign from malignant thyroid nodules, thereby providing a reference for optimizing clinical diagnostic protocols. A total of 120 patients with thyroid nodules who presented for treatment between January 2024 and January 2025 were recruited and randomly assigned to a control group (n=60) or a study group (n=60). The control group underwent a conventional ultrasound examination, while the study group received a high-frequency ultrasound examination. The diagnostic agreement rate, sensitivity, specificity, positive predictive value, and negative predictive value were compared between the two groups. The study group exhibited a significantly higher diagnostic agreement rate than the control group (P<0.01), with superior sensitivity and specificity (P<0.05). Additionally, high-frequency ultrasound yielded a markedly higher detection rate of microcalcifications compared to conventional ultrasound (P<0.01), and the study group showed lower rates of misdiagnosis and missed diagnosis than the control group. By enhancing spatial resolution, high-frequency ultrasound enables clear visualization of the internal microstructure of thyroid nodules, significantly improving the accuracy of differentiating benign from malignant lesions. It is particularly suitable for early screening of small nodules and is worthy of clinical promotion and application.