Application of Grayscale Contrast-Enhanced Ultrasonography in the Diagnosis of Thyroid Nodules

The Objective is to investigate the application value of grayscale contrast-enhanced ultrasonography in the diagnosis of thyroid nodules. Sixty patients with suspected thyroid nodules, admitted between January 2024 and January 2025, were randomized into two groups: the control group and the study group. The control group (n=30) underwent conventional ultrasonography, whereas the study group (n=30) received grayscale contrast-enhanced ultrasonography. With postoperative pathology or fine-needle aspiration biopsy as the gold standard, we compared the sensitivity, specificity, accuracy, and consistency of the two diagnostic modalities. The diagnostic performance of the study group in differentiating benign from malignant thyroid nodules was significantly superior to that of the control group. Grayscale contrast-enhanced ultrasonography demonstrated higher sensitivity, specificity, and accuracy compared with conventional ultrasonography. Kappa test results indicated that the agreement between grayscale contrast-enhanced ultrasonography and pathological diagnosis was significantly higher than that between conventional ultrasonography and pathological diagnosis (P<0.05). Grayscale contrast-enhanced ultrasonography significantly enhances the diagnostic accuracy of thyroid nodules, particularly exhibiting high sensitivity and specificity in distinguishing benign from malignant lesions. It offers more robust diagnostic evidence for clinical practice and holds substantial clinical application value.