Mechanisms and Treatment Strategies of Motor Complications in Parkinson's Disease Patients

The sports complications of Parkinson's disease (PD) seriously affect the quality of life of patients. This article discusses its related contents in depth. This article expounds the pathogenesis of sports complications in neurotransmitter imbalance, neuroplasticity changes, genes and genetic factors and other related factors (age, course of disease, severity of disease, brain inflammation, oxidative stress, etc.). In terms of treatment strategy, drug therapy includes adjusting the dosage, dosage form and frequency of administration of existing drugs such as levodopa, combined application of dopamine receptor agonists, monoamine oxidase -B inhibitors, and auxiliary drugs such as COMT inhibitors, while paying attention to the research and development progress of new drugs. Surgical treatment includes deep brain stimulation (DBS) and other operations such as nucleus destruction, emerging stem cell transplantation and gene therapy. Rehabilitation treatment covers physics, homework, speech therapy and so on. Various treatment strategies have their own characteristics and limitations, and multi-pronged approach is expected to improve the status of patients with PD motor complications.