Crotalaria Multibracteata in Sustainable Therapeutics: Integrating Traditional Knowledge with Green Science

Introduction: Medicinal plants serve as a crucial reservoir for novel therapeutic agents, with Crotalaria multibracteata emerging as a species of significant interest due to its traditional medicinal uses and bioactive potential within the Crotalaria genus. Methods: This review compiles published data on C. multibracteata, including its botanical traits, ethnomedicinal uses, phytochemistry, pharmacology, toxicity, and biotechnological potential. Literature was selected from databases such as PubMed, Scopus, Web of Science, and Google Scholar using relevant keywords. Only peer-reviewed, English-language studies were included. Extraction and isolation techniques like solvent extraction, chromatography, and spectroscopy are also summarized. Results: Phytochemical investigations reveal diverse compounds, including flavonoids, alkaloids, terpenoids, and phenolics, which contribute to demonstrated antioxidant, anti-inflammatory, antimicrobial, and anticancer activities validated through in vitro and in vivo studies. However, toxicological data remain scarce, necessitating further investigation. Conclusion: Crotalaria multibracteata exhibits promising pharmacological properties and therapeutic potential, yet comprehensive studies on safety, mechanisms of action, and cultivation practices are required. Interdisciplinary research approaches will be vital to fully harness its medicinal value and translate traditional knowledge into clinical applications.