A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clustering

Mass Spectrometry Imaging An innovative mass spectrometry imaging approach enables rapid visualization of drug distribution across skin layers. This approach integrates desorption electrospray ionization mass spectrometry imaging with an automated computational tool. Three nanoscale delivery systems for antifungal terbinafine, ethosomes, transethosomes, and microemulsion, were designed and evaluated. Distinct permeation profiles were observed, with transethosomes achieving the deepest dermal delivery. More in article number 2500061, Katherine Margulis and co-workers. Art by the team of INMYWORK Studio.