Chloroquine mitigates long-term effects of in vitro culture in mouse embryos
These findings suggest that inhibiting autophagy during preimplantation development may mitigate the long-term effects of <i>in vitro</i> culture and support normal postnatal growth and metabolism. Thus, autophagy activity in early development may be a key cellular process underlying long term effects observed at later stages.
Authors
- Satoshi Kishigami (ORCID: https://orcid.org/0000-0001-9447-5100)
- Md. Wasim Bari (ORCID: https://orcid.org/0000-0002-0813-3081)
- Kaname Sato (ORCID: https://orcid.org/0000-0003-2510-444X)
- Itsuki Koide
Institutions
- University of Yamanashi (JP)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fcell.2025.1640986
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32