Machine learning identifies PYGM as a macrophage polarization–linked metabolic biomarker in rectal cancer prognosis
This study firstly highlights <i>PYGM</i> as a key metabolic and immunological regulator in rectal cancer, with significant prognostic and therapeutic implications. MPGS and <i>PYGM</i> may serve as novel biomarkers for risk stratification and guide personalized treatment strategies in patients with rectal adenocarcinoma.
Authors
- Chengyuan Xu (ORCID: https://orcid.org/0000-0002-2149-9934)
- Zicheng Yu (ORCID: https://orcid.org/0000-0003-2358-2712)
- Siqi Zhang (ORCID: https://orcid.org/0000-0002-9815-4395)
- Hailong Liu (ORCID: https://orcid.org/0000-0001-8335-7272)
- Bin Sun (ORCID: https://orcid.org/0000-0003-1768-6734)
Institutions
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1639303
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00