NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration
Memantine-preconditioned EVs (M-EVs) exhibit superior neurorestorative capacity via miRNA-mediated mechanisms, offering a promising translational approach for stroke therapy. The study highlights the potential of microenvironment-tailored EVs in neural repair.
Authors
- Li Zhong (ORCID: https://orcid.org/0000-0003-3094-4806)
- Hongtao Tian (ORCID: https://orcid.org/0000-0002-3079-0125)
- Haimei Bo
- Xiaolu Zhang (ORCID: https://orcid.org/0000-0002-9350-2880)
Institutions
- Chengde Medical University (CN)
- Baotou Medical College (CN)
- Hebei University (CN)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fncel.2025.1608615
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81