Arterial compliance is improved via enteral serine protease inhibition in experimental trauma/hemorrhagic shock
Experimental T/HS results in impaired AC, which is partially attenuated by enteral GM administration. Vascular biomechanical impairment may underlie the unrestored MAP in fulminant shock. By targeting modulators of AC, with enteral serine protease inhibition as an adjunct intervention, hemodynamic stability and patient outcomes may be improved in T/HS.
Authors
- Maria Cláudia Irigoyen (ORCID: https://orcid.org/0000-0003-2097-3662)
- Luciano de Figueiredo Borges
- Erik B. Kistler (ORCID: https://orcid.org/0000-0002-6512-4798)
- Cynthia R. Muller (ORCID: https://orcid.org/0000-0003-4698-8168)
- Nathalia Juocys Dias Moreira (ORCID: https://orcid.org/0000-0003-1107-7129)
- Joyce B. Li (ORCID: https://orcid.org/0000-0002-9170-8017)
- Fernando dos Santos (ORCID: https://orcid.org/0000-0002-9147-5137)
- Geert W. Schmid‐Schönbein (ORCID: https://orcid.org/0000-0002-1615-0279)
Institutions
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- La Jolla Bioengineering Institute (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fphys.2025.1655946
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00