Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease
The results indicate that certain changes in cortical shape features are associated with particular cognitive function scores. Surface-based morphometric features of SD and LGI provided complementary results to CT analyses. Region-specific changes in SD and LGI could be useful imaging markers to predict cognitive decline in AD patients.
Authors
- Cheong Hoon Seo (ORCID: https://orcid.org/0000-0003-4091-6382)
- Beomseok Sohn (ORCID: https://orcid.org/0000-0002-6765-8056)
- Yongsik Sim (ORCID: https://orcid.org/0000-0003-2711-2793)
- Byoung Seok Ye (ORCID: https://orcid.org/0000-0003-0187-8440)
- Young‐gun Lee (ORCID: https://orcid.org/0000-0003-0460-455X)
- Ilwoo Lyu (ORCID: https://orcid.org/0000-0001-5868-9603)
Institutions
- Pohang University of Science and Technology (KR)
- Yonsei University (KR)
- Samsung Medical Center (KR)
- Inje University Ilsan Paik Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fnagi.2025.1635861
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Ministry of Education
- Bracco Imaging