Effect of transcutaneous auricular vagus nerve stimulation on postoperative liver function in patients undergoing partial hepatectomy: a study protocol for a prospective, double-blind, randomized controlled trial
Postoperative liver function dysfunction following partial hepatectomy remains a significant clinical complication that negatively impacts patient prognosis and long-term survival outcomes. TaVNS, an emerging non-invasive neuromodulation technique, has demonstrated considerable potential for perioperative organ protection in preclinical studies. This study aims to provide robust evidence regarding the therapeutic efficacy of taVNS in reducing hepatic injury after partial hepatectomy. By introducing a novel approach to perioperative hepatic protection, taVNS may contribute valuable insights into the development of multimodal hepatoprotective strategies.
Authors
- Xingyu Xiong (ORCID: https://orcid.org/0009-0002-7562-1066)
- Mingshu Tao
- Chenchen Hang
- Zhichao Sun (ORCID: https://orcid.org/0000-0002-4167-236X)
- Yu‐Cheng Lin (ORCID: https://orcid.org/0000-0003-2264-4491)
- Jun‐Li Cao (ORCID: https://orcid.org/0000-0002-8932-4743)
- He Liu (ORCID: https://orcid.org/0000-0002-4103-312X)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-1984-1136)
- Xiaoqin Guo (ORCID: https://orcid.org/0000-0003-1647-4385)
- Mingyuan Wang (ORCID: https://orcid.org/0000-0002-9050-7483)
- Jinling Liu (ORCID: https://orcid.org/0000-0002-9989-6550)
- Wenxin Zhao
- Wen Tan
Institutions
- Xuzhou Medical College (CN)
- Huzhou Normal University (CN)
- Huzhou Central Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fmed.2025.1603543
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University of Electronic Science and Technology of China
- Natural Science Foundation of Zhejiang Province