Revealing lactylation-mediated mechanisms and hub genes in heart failure pathogenesis
Lactylation plays a crucial role in the pathogenesis of HF, with genes such as GATA2, HBB, JAK2, STAT2, STAT4, and WARS2 emerging as potential lactylation biomarkers for HF identification. The lactylation-macrophage polarization-inflammation axis stands out as a pivotal mechanism driving HF progression.
Authors
- Lili Zhang (ORCID: https://orcid.org/0000-0003-4902-7522)
- Xing Zhu (ORCID: https://orcid.org/0000-0003-1863-7766)
- Hui Niu (ORCID: https://orcid.org/0000-0003-4611-1614)
- Hongguang Jin
- Hongguang Xie
- Yiqiang Wang (ORCID: https://orcid.org/0009-0003-9666-3967)
Institutions
- BaiCheng Normal University (CN)
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fcvm.2025.1622958
- Citations
- 3
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- People's Government of Jilin Province
- Department of Science and Technology of Jilin Province