Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease
MD alleviates MASLD progression by synergistically improving hepatic metabolic homeostasis and gut microbiota composition, demonstrating superior efficacy over NC in mitigating inflammation, enriching beneficial microbes, and regulating microbial metabolism. These findings highlight MD's potential as a targeted dietary intervention for MASLD.
Authors
- Ge Chen (ORCID: https://orcid.org/0000-0003-1758-747X)
- Shunshun Jiang
- Tingting Xu (ORCID: https://orcid.org/0000-0003-4965-4307)
- Lingling Kong (ORCID: https://orcid.org/0000-0002-6266-9741)
- Zixuan Wang (ORCID: https://orcid.org/0000-0001-5116-496X)
- Xutong Sun
- Jia Xiao (ORCID: https://orcid.org/0000-0001-5604-2494)
- Meijiao Wang (ORCID: https://orcid.org/0000-0002-0514-7891)
- Hong Zhao (ORCID: https://orcid.org/0000-0002-7291-1685)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fnut.2025.1644014
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Qingdao University