Effects of angiotensin receptor–neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure
ARNI significantly reduced MEE compared with ACEI/ARB. MEE was significantly associated with the severity of left ventricular systolic dysfunction and long-term prognosis. An MEE value over 178 kcal/min was a powerful predictor of cardiac death and linked with increased risk of 1-year all-cause mortality in patients with AMI complicated by HF.
Authors
- Chew W. Cheng
- Yu Nie (ORCID: https://orcid.org/0000-0002-8744-0046)
- Di Chen (ORCID: https://orcid.org/0000-0002-0243-510X)
- Qin Yu (ORCID: https://orcid.org/0000-0001-8448-8637)
- Yan Yang (ORCID: https://orcid.org/0000-0002-8320-5225)
- Shunji Liang
Institutions
- Dalian Medical University (CN)
- 117th Hospital of People's Liberation Army (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fcvm.2025.1550624
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China