Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T
Our findings demonstrate that OVV-01 not only possesses potent direct oncolytic activity but also enhances the efficacy of adoptive T cell therapy by improving antigen presentation and T cell activation. This dual mechanism provides a rationale for using OVV-01 in combination immunotherapy strategies targeting solid tumors.
Authors
- Liang Mao (ORCID: https://orcid.org/0000-0001-9836-8740)
- Rong Xu (ORCID: https://orcid.org/0000-0002-9087-2982)
- Liang Ma (ORCID: https://orcid.org/0000-0003-3222-0342)
- Guoqing Zhou
- Lin Cheng (ORCID: https://orcid.org/0000-0001-6962-0302)
- Xiangxiang Wang (ORCID: https://orcid.org/0009-0001-8030-4965)
- Qibin Ma (ORCID: https://orcid.org/0000-0003-3331-3399)
Institutions
- Advisory Board Company (United States) (US)
- Bioscience Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1617941
- Citations
- 1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.82