Association between hyperuricemia, hypertension, dyslipidemia and cardiovascular events in a large East Siberian region

Aim. To assess the association between hyperuricemia (HU), as well as its combination with hypertension (HTN), dyslipidemia and car­dio­vascular events. Material and methods . This retrospective analysis included a re­presentative sample of 1603 residents of Krasnoyarsk Krai aged 25-64 years from the Russian epidemiological study ESSE RF. Uric acid >360 μmol/l was taken as the HU criterion. Statistical processing included logistic regression with sequential exclusion of insignificant factors to search for associations between HU, HTN and lipid metabolism disorders with cardiovascular events — stroke, myocardial infarction (MI) and coronary artery disease (CAD). Results. The prevalence of HU was 34,6%, among men — 47,6%, among women — 26,1%. No significant differences in the frequency of MI, stroke and CAD among individuals with and without HU were found. Regression model revealed a significant increase in the risk of stroke (odds ratio (OR) 5,7; 95% confidence interval (CI): 1,68-19,34) and CAD (OR 4,99; 95% CI: 2,73-9,09), but not MI, as well as stroke (OR 2,95; 95% CI: 1,31-6,64) (p=0,009), but not MI and CAD, when HU was combined with HTN. Conclusion. No significant association was found between HU and cardiovascular events. However, the combination of HU with HTN, as well as HU with low high-density lipoprotein cholesterol, was significantly associated with stroke and CAD.