Novel Interleukin-11 Inhibitors Attenuate Collagen Production in Patient-Derived Synovial Fibroblasts
Our findings demonstrate a strong connection between IL-11 and synovial fibrosis status in patients with advanced kOA, indicating that IL-11 is a key mediator of this process. The ability of the new NMX compounds to significantly reduce fibrotic markers in patient-derived cells offers a promising preclinical basis for developing targeted therapies to prevent or treat AF attributable to kOA or other arthropathies and traumatic joint injuries.
Authors
- Cathy A. Swindlehurst
- Luis Marrero (ORCID: https://orcid.org/0000-0001-8252-2133)
- Sarah Miller (ORCID: https://orcid.org/0009-0001-0754-1673)
- E Richard
- Ryan M. Schroeder
- Miguel A. De Jesus
- Steven Saweikis
- Molly Chaffee
Institutions
- NovoMedix (United States) (US)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Cureus
- Published
- 2025-08-11
- DOI
- https://doi.org/10.7759/cureus.89850
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00