TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression
Our study provides the first evidence that TATA-binding protein-associated factor 15 regulates tumor-associated macrophages polarization through the SOCS1/JAK2/STAT1 axis, unveiling a novel immunotherapeutic target for cholangiocarcinoma. The developed M2pep-LNP-siTAF15 nanodelivery system not only overcomes the challenge of targeted delivery, but its remarkable antitumor efficacy highlights strong potential for clinical translation. This work fundamentally advances our understanding of stromal-immune crosstalk in cholangiocarcinoma while offering a clinically actionable therapeutic strategy.
Authors
- Jingjing Wei (ORCID: https://orcid.org/0000-0002-2197-8062)
- Hong‐Wen Liu (ORCID: https://orcid.org/0000-0001-8757-1620)
- Suzhen Yang (ORCID: https://orcid.org/0000-0002-0955-112X)
- Lin Zhou (ORCID: https://orcid.org/0000-0001-5689-3512)
- Shanshan Shen (ORCID: https://orcid.org/0000-0003-3249-1564)
- Tianming Zhao (ORCID: https://orcid.org/0000-0002-1782-4781)
- Ge Bai (ORCID: https://orcid.org/0000-0002-2878-1772)
- Yun Zhu (ORCID: https://orcid.org/0000-0002-1299-6509)
- Zhangding Wang (ORCID: https://orcid.org/0000-0002-3959-4542)
- Yu Liu (ORCID: https://orcid.org/0000-0001-6612-6827)
- Lei Wang (ORCID: https://orcid.org/0000-0002-3392-3712)
- Lei Wang (ORCID: https://orcid.org/0009-0005-0050-0691)
- Lei Xu (ORCID: https://orcid.org/0009-0004-1374-2211)
- Bing Xu (ORCID: https://orcid.org/0000-0002-4639-387X)
- Nannan Zhang (ORCID: https://orcid.org/0000-0003-0582-8934)
- Xin Fu (ORCID: https://orcid.org/0000-0001-9726-9388)
- Zhao Si
- Qi Chen
- Yu‐Guang Zhou (ORCID: https://orcid.org/0000-0001-5887-9781)
- Yue Zhou
- Yani Pan
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101545
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Jiangsu Provincial Key Research and Development Program
- Key Project of Science and Technology Development of Nanjing Medicine
- Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau