The Flavonoids Content of Graptophyllum pictum (L.) Griff as an Antiplatelet Aggregation and Anti-inflammatory Agent: A Systematic Literature Review

Graptophyllum pictum (L.) Griff., a shrubby stove plant, has been traditionally used to treat various diseases. This study aims to determine the antiinflammatory and antiplatelet aggregation activities of the ethanolic extract of Graptophyllum pictum. A systematic literature review was conducted from January 2014 until December 2024. Articles were identified according to the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines, with data collected from ScienceDirect, SpringerLink, and PubMed. Medical Subject Headings (MeSH) were utilized with various terminology: "Graptophyllum pictum (L.) Griff”, "antiplatelet aggregation”, and “antiinflammatory”. The inclusion criteria were: (1) resources categorized as original research reports, case reports, case studies, letters to the editor, brief communications, commentaries, editorials, and news; (2) publications with accessible full text; and (3) articles providing information on the Graptophyllum pictum (L.) Griff. The exclusion criteria were papers categorized as systematic reviews, meta-analyses, or bibliometric analyses. The findings suggest that Graptophyllum pictum contains bioactive compounds such as flavonoids, alkaloids, and saponins, which contribute to its anti-inflammatory and antiplatelet properties.