Development and Optimization of Chamomile Extract Pastilles for Potential Oral Ulcer Treatment

Objectives: This study aimed to develop and optimize chamomile extract pastilles as apotential therapeutic option for oral ulcer treatment, focusing on masking chamomile’sbitterness, ensuring stability, and achieving controlled release of active constituents toenhance patient compliance. Methods: Chamomile (Matricaria chamomilla L.) extract was prepared via percolationusing 80% ethanol. Pastilles were formulated with gelatin, xylitol, aspartame, citricacid, and flavoring agents (eucalyptus, lemon, raspberry, cola). Physical properties(smoothness, elasticity, color), sensory acceptability (rated by 10 volunteers), quercetincontent (UV-Vis spectrophotometry), and dissolution profiles (in artificial saliva, pH 6.8)were assessed. Sensory scores were analyzed using one-way ANOVA with Tukey’s posthoc tests (p < 0.05).. Results: Formulations J1 and J2, incorporating citric acid, exhibited significantly highersensory scores (p < 0.0001) than G1–G3, effectively masking bitterness. Quercetincontent indicated 85–89% loading efficiency across formulations. Dissolution testsshowed controlled release of chamomile extract from J2 pastilles compared to pureextract, with stable release over 60 minutes. Physical assessments confirmed smooth,cohesive pastilles with favorable elasticity. Conclusion: Chamomile extract pastilles represent a promising formulation withpotential for oral ulcer treatment, offering improved palatability and controlled release.Their natural composition and high acceptability suggest potential for pediatric and adultuse, warranting further clinical trials to validate efficacy and long-term stability.