Beta Boswellic Acid Reduces Tau Phosphorylation Level and Enhances Reelin Expression in the brain

Objectives: Learning and memory retention involve a permanent change in behavior based on environmental adaptation. Reelin protein plays a role in learning and memory but has not been extensively studied in the presence of herbal components. This study examines the effect of an optimum dose of beta-boswellic acid (BBA) on reducing tau phosphorylation levels and enhancing Reelin expression in the hippocampus to improve cognitive behavioral outcomes.. Methods: Spatial memory, learning, and locomotor activity were assessed. Histological and Western blot analyses were performed. Results: The findings demonstrate a significant effect of BBA (35 μg/kg body weight) on memory consolidation during the probe trial of the Morris Water Maze (MWM) test. BBA treatment reduced the formation of dark neurons in the hippocampus and promoted Reelin expression. Conclusion: A specific dose of BBA enhanced memory consolidation in adult rats, with increased Reelin protein expression—likely due to BBA’s anti-inflammatory properties, a key factor contributing to improved memory performance.