A case–control study on the individualized use of opioid analgesics based on single-nucleotide polymorphism
<i>OPRM1</i> (rs1799971) AA genotype patients have a higher risk of ADR. <i>OPRM1</i> AA genotype patients should pay more attention to ADR, and the dosage can be initiated at low levels. The association between dose demand and SNPs still needs to be evaluated in larger cohorts. Meanwhile, particular attention should be given to the <i>ABCB1</i> gene.
Authors
- Shengmei Zhou (ORCID: https://orcid.org/0000-0002-1917-5543)
- Lei Zheng (ORCID: https://orcid.org/0000-0003-2576-8780)
- Chao Song (ORCID: https://orcid.org/0000-0001-9434-2973)
- Zheng Fu (ORCID: https://orcid.org/0000-0002-7483-832X)
- Lijun Sun (ORCID: https://orcid.org/0000-0002-8380-1721)
- Jing Yang (ORCID: https://orcid.org/0000-0002-2469-5471)
Institutions
- Shandong University (CN)
- Shandong First Medical University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fphar.2025.1629866
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- Natural Science Foundation of Shandong Province