Mechanistic Perspectives on Radiation-Induced Skin Injury and the Protective Effects of Berberine
Radiation injury leads to persistent senescence, inflammation, and impaired wound healing in skin tissues. CDKN1A, IGFBP7, and CTSL are core senescence markers in RISI. By downregulating the expression of senescence markers and suppressing inflammatory pathways (including p53, ROS, and JAK-STAT), BBR accelerates radiation-induced wound healing, offering a novel therapeutic strategy for managing RISI.
Authors
- Fenghao Geng (ORCID: https://orcid.org/0000-0002-0559-3701)
- Long Yang (ORCID: https://orcid.org/0000-0002-9990-8398)
- Chen Gong (ORCID: https://orcid.org/0000-0002-4092-9856)
- Tao Yan (ORCID: https://orcid.org/0000-0002-1217-3705)
- Xiaolan Ou
- Shuyu Zhang (ORCID: https://orcid.org/0000-0003-1419-3635)
- Daojiang Yu (ORCID: https://orcid.org/0000-0002-8571-930X)
- Zehua Zhou (ORCID: https://orcid.org/0000-0002-7373-078X)
- Biao Huang (ORCID: https://orcid.org/0000-0001-9403-4508)
- Tong He (ORCID: https://orcid.org/0000-0003-3149-7243)
- Guozhong Lyu
Institutions
- Jiangnan University (CN)
- Chengdu Medical College (CN)
- West China Medical Center of Sichuan University (CN)
- Wuxi Fourth People's Hospital (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s523616
- Citations
- 2
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.72