Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization
This study establishes a hierarchical metabolic framework for depression, prioritizing single-carbon metabolism and oxidative stress as central therapeutic targets. The findings emphasize methylation dysregulation and mitochondrial dysfunction in elderly depression, offering novel biomarkers for precision intervention.
Authors
- Yangfei Zhao (ORCID: https://orcid.org/0000-0002-8375-5091)
- Jiang Xu (ORCID: https://orcid.org/0000-0002-0978-4310)
- Peipei Han (ORCID: https://orcid.org/0000-0002-2947-917X)
- Xiaojun Wang (ORCID: https://orcid.org/0000-0003-4521-4099)
- Xiaoyu Chen (ORCID: https://orcid.org/0000-0003-4009-8156)
- Qi Guo (ORCID: https://orcid.org/0000-0002-0193-4388)
- Jinwen Zhang (ORCID: https://orcid.org/0000-0003-3728-0264)
- Wu Qianhao
- Miao Jingjie
- Yao Wenxiu
Institutions
- Shanghai Medical Information Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fpsyt.2025.1627020
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality