In-silico Analysis of a Novel MCR-1.1 Variant on an IncX4 Plasmid Attenuating Colistin Resistance in Multidrug-Resistant Escherichia coli ST131
This novel mcr-1.1 variant potentially restores colistin susceptibility in a globally prevalent <i>E. coli</i> lineage. The findings highlight a unique resistance attenuation mechanism and offer a promising avenue for restoring colistin efficacy. Further <i>in-vivo</i> validation is warranted to explore therapeutic strategies exploiting such mutations.
Authors
- Sandip Patil (ORCID: https://orcid.org/0000-0003-2736-9206)
- Xinye Li (ORCID: https://orcid.org/0000-0001-8131-4981)
- Sixi Liu
- Hongyu Chen (ORCID: https://orcid.org/0000-0003-1644-3327)
- Yunsheng Chen (ORCID: https://orcid.org/0000-0002-8520-9852)
- Feiqiu Wen
- Xiaowen Chen (ORCID: https://orcid.org/0000-0002-5025-3423)
Institutions
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Shenzhen Children's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/idr.s539110
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59