Dysregulation of G protein subunits in autism: decreased GNAO1 and elevated GNAI1 levels in ASD
Our findings suggest that dysregulation of G protein signaling pathways, characterized by reduced GNAO1 and increased GNAI1 levels, may contribute to underlying mechanisms of ASD. Further research is warranted to clarify the mechanistic roles of these subunits in ASD and their potential as biomarkers or therapeutic targets.
Authors
- Tuba Edgünlü (ORCID: https://orcid.org/0000-0002-9300-9324)
- Çilem Özdemir (ORCID: https://orcid.org/0000-0002-3821-3621)
- Yaşar Topal (ORCID: https://orcid.org/0000-0002-7059-4823)
- Nilfer Şahın (ORCID: https://orcid.org/0000-0001-7120-1561)
- Hatice Topal (ORCID: https://orcid.org/0000-0003-3226-0205)
- Gülsüm Demirkan Başkaya (ORCID: https://orcid.org/0000-0002-9444-7035)
- Özlem Nehir Yazici (ORCID: https://orcid.org/0000-0002-8003-7860)
Institutions
- Muğla University (TR)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fpsyt.2025.1587727
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00