GGTLC1 Is a Prognostic Biomarker in Renal Clear Cell Carcinoma
Kidney renal clear cell carcinoma (KIRC), the most common type of renal cell carcinoma, is an immunobiologically and metabolically distinct tumor. Its clinical management is closely related to the tumor microenvironment (TME). Identifying its potential markers is important for improving prognosis. Therefore, in this study, we successfully constructed a prognostic model of glutathione metabolism-related molecules and screened for GGTLC1 prognostic molecules, while immunohistochemical analysis of the online database HPA and hospital patient specimens showed that GGTLC1 was highly expressed in paracancerous tissues. Taken together, the results of this study suggest that GGTLC1 is a potential prognostic biomarker associated with KIRC. <b>Trial Registration:</b> Chinese Clinical Trial Registry identifier: LSKY: 2022-112-01.
Authors
- Guanghai Yu (ORCID: https://orcid.org/0000-0003-1429-6837)
- Jianbo Wang (ORCID: https://orcid.org/0000-0002-2667-3946)
- Lijun Shi (ORCID: https://orcid.org/0009-0002-8658-0685)
- Xiaofeng Tao (ORCID: https://orcid.org/0000-0002-8472-0456)
- Shi Li
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- Dalian Municipal Central Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- International Journal of Genomics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/ijog/7524935
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00