Dihydroartemisinin decreases pre-existing neutralizing antibodies against adeno-associated virus in challenged mice
These findings suggest that DHA is a safe and effective agent for modulating humoral immune responses to AAV vectors. Our results provide proof-of-concept evidence supporting the use of TCM-derived compounds to address immunological barriers in gene therapy.
Authors
- Sana Shaheen
- Ming Yang (ORCID: https://orcid.org/0000-0002-6367-8199)
- Binbin Cheng
- Jinyan Xie (ORCID: https://orcid.org/0000-0002-5406-4195)
- Shao‐Lai Zhou (ORCID: https://orcid.org/0000-0002-8526-5221)
- Zhengjun Zhou (ORCID: https://orcid.org/0000-0001-8540-7683)
- Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
- Yun He
- Jingjing Fang (ORCID: https://orcid.org/0000-0002-4942-0976)
- Xuxia Gao
- Changquan Ling
- Enze Cui
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Changhai Hospital (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.3389/fphar.2025.1587135
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China