A carrier-free nano-photosensitizer for red light-activated NO release and combination therapy
In this work, multifunctional nanoparticles (A-PIB NPs) constructed by a nitric oxide (NO) donor, L-arginine, and a boron dipyrromethene derivative were used for red light-responsive and spatiotemporally-controllable NO release. A-PIB NPs could produce singlet oxygen and NO under 630 nm light irradiation, achieving controlled release of NO and being used for combination therapy of tumors.
Authors
- Wenhai Lin (ORCID: https://orcid.org/0000-0003-4928-8183)
- Qiong Lin (ORCID: https://orcid.org/0000-0003-2736-9038)
- Jun Jia (ORCID: https://orcid.org/0009-0000-8179-1876)
- Chaonan Li (ORCID: https://orcid.org/0000-0002-1141-3949)
- Huixuan Qi (ORCID: https://orcid.org/0009-0002-5884-7661)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Soochow University (CN)
- Wuhan Technology and Business University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00959f
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00