PREOPERATIVE USE OF PLATELET-RICH PLASMA IN COMBINATION WITH STROMAL VASCULAR FRACTION IN TREATMENT OF LONG NON-HEALING WOUNDS

Aim . Comparative morphometric, histological, and histochemical evaluation of the efficacy of combined application of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) in the treatment of long non-healing wounds in an experi- mental model. Materials and methods . A randomized experimental study was conducted on 32 rabbits. Excisional wounds with a diameter of 2 cm were created on the animals' backs. The animals were randomly divided into four groups: control group (standard treatment), group with preoperative treatment using physiological saline, group with preoperative PRP+SVF injection, and group with both preoperative and postoperative PRP+SVF injections. The effectiveness was assessed using morphometric, histological, and histochemical methods. Results . The combined use of PRP and SVF enhanced angiogenesis, stimulated collagen synthesis, and reduced inflammatory cell infiltration. Conclusion . The combined use of PRP and SVF significantly improves tissue regeneration quality and may be an effective method for the treatment of chronic wounds.