ADVANCES IN THE USE OF PLATELET-RICH PLASMA AND ADIPOSE TISSUE DERIVATIVES IN SURGICAL REGENERATIVE MEDICINE

Background. Adipose-derived tissues and platelet-rich plasma (PRP) have emerged as promising agents in regenerative medicine and aesthetic surgery due to their ability to stimulate tissue repair, enhance angiogenesis, and reduce inflammation. Their combined use has gained increasing attention in reconstructive and plastic surgical practices. Aim. This review aims to evaluate the biological functions and clinical potential of adipose tissue derivatives and PRP in surgical applications, particularly in enhancing fat graft survival and promoting tissue regeneration. A systematic review of scientific literature was performed using databases such as PubMed , Scopus , and Web of Science , following PRISMA guidelines. The selection criteria included original studies, reviews, and clinical trials focused on the biological properties, therapeutic mechanisms, and surgical outcomes associated with the use of adipose tissue and PRP. Adipose tissue contains multipotent mesenchymal stem cells that contribute to neovascularization, immune modulation, and extracellular matrix remodeling. PRP is rich in growth factors that support cellular proliferation, tissue integration, and inflammation control. The co-administration of PRP with fat grafts improves graft retention and healing outcomes. Several clinical studies demonstrate enhanced aesthetic and functional results in procedures involving facial reconstruction, wound healing, and breast surgery. Conclusion. The integration of PRP and adipose-derived therapies offers significant advantages in surgical regenerative strategies. However, heterogeneity in preparation methods and application protocols limits comparability across studies. Further research is necessary to standardize techniques, validate outcomes, and broaden the clinical applicability of these regenerative modalities.