Downregulated RSAD2 Attenuates the Apoptosis of LPS-Stimulated RAW264.7 via NF-κB Signaling Pathway

Our findings suggested that RSAD2 knockdown alleviated LPS-induced apoptosis in RAW264.7 macrophages by suppressing the NF-κB signaling pathway, highlighting RSAD2 as a potential therapeutic target for sepsis-related macrophage dysfunction.

Authors

Ri Tang (ORCID: https://orcid.org/0000-0003-0137-2917)
Haixia Wang (ORCID: https://orcid.org/0000-0001-9789-997X)
Mengxi Huang (ORCID: https://orcid.org/0000-0002-9274-6023)
Rongheng Liao (ORCID: https://orcid.org/0009-0006-1530-4180)
Zhen Qi (ORCID: https://orcid.org/0000-0002-4687-5422)
Kongli Lu

Institutions

Central South University (CN)
Shanghai Jiao Tong University (CN)
Renji Hospital (CN)
Erasmus MC (NL)
Second Xiangya Hospital of Central South University (CN)
Erasmus University Rotterdam (NL)

Publication Details

Journal: Journal of Inflammation Research
Published: 2025-08-01
DOI: https://doi.org/10.2147/jir.s535225
Citations: 1
Primary Topic: Signaling Pathways in Disease
Type: article
Field-Weighted Citation Impact: 0.81

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article

Downregulated RSAD2 Attenuates the Apoptosis of LPS-Stimulated RAW264.7 via NF-κB Signaling Pathway

Ri Tang, Haixia Wang, Mengxi Huang, Rongheng Liao et al.

Aug 1, 2025

1 citations

Journal of Inflammation Research

Signaling Pathways in Disease

0.81

article

Downregulated RSAD2 Attenuates the Apoptosis of LPS-Stimulated RAW264.7 via NF-κB Signaling Pathway

Ri Tang, Haixia Wang, Mengxi Huang, Rongheng Liao, Zhen Qi, Kongli Lu

August 1, 2025article en

1 citations

Abstract

Our findings suggested that RSAD2 knockdown alleviated LPS-induced apoptosis in RAW264.7 macrophages by suppressing the NF-κB signaling pathway, highlighting RSAD2 as a potential therapeutic target for sepsis-related macrophage dysfunction.

Journal of Inflammation ResearchVol. Volume 18

Central South University (CN), Shanghai Jiao Tong University (CN), Renji Hospital (CN), Erasmus MC (NL), Second Xiangya Hospital of Central South University (CN), Erasmus University Rotterdam (NL)

Zero hunger

Openalex Percentile: Top 25%

Signaling Pathways in Disease

0.81

DOI Open Access PDF OpenAlex

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Downregulated RSAD2 Attenuates the Apoptosis of LPS-Stimulated RAW264.7 via NF-κB Signaling Pathway — Ri Tang, Haixia Wang, et al. · Journal of Inflammation Research (2025) | TGRS Research Map | TGRS