Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis
Our results revealed that the ratio of <i>Bacteroidetes/Firmicutes</i> and low levels of acetate play important regulatory roles in AD, and exogenous supplementation of acetate can alleviate DNCB-induced AD in mice through the FFAR2 and Th2 pathways. These findings provide valuable insights into the mechanisms of AD occurrence and progression, microbial community dynamics, metabolic regulation, and functional food innovation.
Authors
- Xiumei Mo (ORCID: https://orcid.org/0000-0001-9238-6171)
- Feng Luo (ORCID: https://orcid.org/0000-0003-3442-3987)
- Dacan Chen (ORCID: https://orcid.org/0000-0002-7300-194X)
- Jingwen Wang (ORCID: https://orcid.org/0000-0002-6794-2604)
- Siqi Ye (ORCID: https://orcid.org/0000-0003-0891-8062)
- Jinjing Jia (ORCID: https://orcid.org/0000-0003-2297-4394)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1595532
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00