Limited 12-hour pharmacokinetic assessment of CBD and CBDA isolates compared to their full-spectrum extracts in healthy adult beagles

CBDA demonstrated superior absorption compared to CBD. No evidence supported enhanced absorption from full-spectrum products, suggesting the "entourage effect" may involve receptor-level interactions rather than absorption. All treatments were well tolerated, with normal CBC and chemistry results, indicating that administering CBD or CBDA, either as isolates or in full-spectrum extracts, at 1 mg/kg every 12 h for 1 week is safe in healthy adult dogs. This is the first comprehensive comparison of full-spectrum, isolate, and acidic cannabinoid forms in dogs.