Psychological distress in older adults: associations with epigenetic markers of ageing, inflammation, and depression, and joint effects on mortality
In older Australians, higher psychological distress was associated with older epigenetic age and higher <i>mCRP</i>. Participants with higher levels of both psychological distress and epigenetic markers of ageing and <i>mCRP</i> had higher mortality risk. These findings highlight links between psychological and biological health, and the potential importance of considering both for disease risk stratification.
Authors
- Pierre‐Antoine Dugué (ORCID: https://orcid.org/0000-0003-2736-3023)
- Graham G. Giles (ORCID: https://orcid.org/0000-0003-4946-9099)
- Roger Laughlin Milne (ORCID: https://orcid.org/0000-0001-5764-7268)
- Danmeng Lily Li (ORCID: https://orcid.org/0009-0006-7799-819X)
- Allison M. Hodge (ORCID: https://orcid.org/0000-0001-5464-2197)
- Melissa C. Southey (ORCID: https://orcid.org/0000-0002-6313-9005)
- Xiaojing Xu (ORCID: https://orcid.org/0000-0003-0469-0224)
Institutions
- The University of Melbourne (AU)
- Cancer Council Victoria (AU)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.bbih.2025.101090
- Citations
- 2
- Primary Topic
- Health disparities and outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- VicHealth
- National Health and Medical Research Council
- Cancer Council Victoria