Identification of Cancer-Associated Proteins in Colorectal Cancer Using Mass Spectrometry
Our findings suggest that proteome abundance trends may contribute to the identification of biomarker candidates and therapeutic targets in colorectal cancer. However, given the limited sample size and lack of subtype stratification, further studies using larger, statistically powered cohorts are warranted to establish clinical relevance. These proteins may provide insights into drug resistance and tumor heterogeneity. Limitations of the study include the inability to detect low-abundance proteins and reliance on protein abundance rather than functional activity. Future complementary approaches, such as affinity proteomics, are suggested to address these limitations.
Authors
- Naoyuki Toyota (ORCID: https://orcid.org/0009-0004-0621-4883)
- Shuhei Iwata (ORCID: https://orcid.org/0000-0002-8115-7354)
- Yusuke Kawashima (ORCID: https://orcid.org/0000-0002-9779-8199)
- Ryo Konno (ORCID: https://orcid.org/0000-0002-4375-1133)
- Rei Noguchi (ORCID: https://orcid.org/0000-0003-1180-2394)
- Tadashi Kondo (ORCID: https://orcid.org/0000-0001-6405-7792)
- Yuki Yoshimatsu (ORCID: https://orcid.org/0000-0002-1131-2988)
- Shin Fujita
- Yoshio Kodera (ORCID: https://orcid.org/0000-0002-6661-8677)
Institutions
- Tochigi Cancer Center (JP)
- Kazusa DNA Research Institute (JP)
- National Cancer Research Institute (GB)
- Kitasato University (JP)
Publication Details
- Journal
- Proteomes
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3390/proteomes13030038
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00