Recurrent Spontaneous Hypothermia in an Elderly Woman: A Rare Neurological Case of Late-Onset Shapiro Syndrome

An 81-year-old woman with a known diagnosis of Shapiro syndrome presented with recurrent hypothermia and delirium. This diagnosis had previously been made following multiple hospital admissions, extensive investigations, and imaging that showed corpus callosum agenesis. Shapiro syndrome is a rare neurological disorder characterised by episodic hypothermia and autonomic dysfunction. Management in this case was guided by an individualised care plan and supportive measures. This report highlights the diagnostic complexity of Shapiro syndrome and the importance of clinical awareness in older adults with unexplained hypothermia.