Transfusion of Amustaline/Glutathione Pathogen-reduced Red Blood Cells in Cardiac Surgery: A Randomized Phase 3 Clinical Trial

The incidence of AKI in recipients of pathogen-reduced red cells was noninferior to conventional red cell transfusion. Treatment-emergent antibodies were uncommon and not clinically significant.

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Publication Details

Journal
Anesthesiology
Published
2025-08-12
DOI
https://doi.org/10.1097/aln.0000000000005716
Citations
2
Primary Topic
Blood transfusion and management
Type
article
Field-Weighted Citation Impact
1.55
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article

Transfusion of Amustaline/Glutathione Pathogen-reduced Red Blood Cells in Cardiac Surgery: A Randomized Phase 3 Clinical Trial

John W. McNeil, Mohamed Alsammak, Richard J. Benjamin, James D. Gorham et al.
2 citations
Anesthesiology
Blood transfusion and management
1.55
article

Transfusion of Amustaline/Glutathione Pathogen-reduced Red Blood Cells in Cardiac Surgery: A Randomized Phase 3 Clinical Trial

John W. McNeil, Mohamed Alsammak, Richard J. Benjamin, James D. Gorham, Michael Sekela, Ronald G. Pearl, Edward L. Snyder, Roman M. Sniecinski, Gregory A. Nuttall, Neel R. Sodha, Thomas M. Beaver, Yoshiya Toyoda, J. Peter R. Pelletier, T. Brett Reece, Ravi Sarode, Ian J. Welsby
article en
2 citations

Abstract

The incidence of AKI in recipients of pathogen-reduced red cells was noninferior to conventional red cell transfusion. Treatment-emergent antibodies were uncommon and not clinically significant.

AnesthesiologyVol. 143(5)
University of Colorado Hospital (US), United Negro College Fund (US), Apple (Israel) (IL), Mayo Clinic (US), UF Health Shands Hospital (US), University of Kentucky (US), Emory University (US), Duke University (US), University of Virginia Health System (US), Rhode Island Hospital (US), Yale University (US), University of Florida (US), Economie Publique (FR), Temple University Hospital (US), Temple University Health System (US), Mayo Clinic in Arizona (US), Duke Medical Center (US), Stanford Medicine (US), Mayo Clinic in Florida (US), Cerus (United States) (US), The University of Texas Southwestern Medical Center (US), University of Colorado Denver (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 16%
Blood transfusion and management
1.55
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