Integrating graph convolutional networks with large language models for structured biomedical material knowledge representation

Automated literature mining is key to building structured biomedical materials databases, yet current methods struggle with large publication volumes, complex entity relations and domain-specific terminology. We propose a hierarchical natural language processing (NLP) framework for extracting structured data from biomedical materials texts. Our pipeline uses named entity recognition (NER) to identify entities such as compositions, synthesis methods and properties. Sentence-level relation extraction captures direct associations (e.g. temperature, morphology), while a paragraph-level graph convolutional network (GCN) module resolves cross-sentence co-references. Rule-based templates enhance precision in specific cases. Extracted relations are integrated into a biomedical materials knowledge graph, enabling scalable and extensible data representation. Experiments show that the sentence-level model achieves 84.7% accuracy and the GCN-based module achieves 84.0%. This approach offers an efficient pipeline for structuring complex scientific texts, reducing manual effort and supporting large-scale knowledge extraction in biomedical materials and related domains.

Authors

Institutions

Publication Details

Journal
Regenerative Biomaterials
Published
2025-01-01
DOI
https://doi.org/10.1093/rb/rbaf083
Primary Topic
Biomedical Text Mining and Ontologies
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Integrating graph convolutional networks with large language models for structured biomedical material knowledge representation

Yao Hou, Yan Zhuang, Xiangdong Zhu, Mingli Yang et al.
Regenerative Biomaterials
Biomedical Text Mining and Ontologies
article

Integrating graph convolutional networks with large language models for structured biomedical material knowledge representation

Yao Hou, Yan Zhuang, Xiangdong Zhu, Mingli Yang, Lin Han, Guangfu Yin, Kan Wang, Ke Chen, Jiangli Lin, Xiangfeng Li, Mufei Li, Xingdong Zhang
article en

Abstract

Automated literature mining is key to building structured biomedical materials databases, yet current methods struggle with large publication volumes, complex entity relations and domain-specific terminology. We propose a hierarchical natural language processing (NLP) framework for extracting structured data from biomedical materials texts. Our pipeline uses named entity recognition (NER) to identify entities such as compositions, synthesis methods and properties. Sentence-level relation extraction captures direct associations (e.g. temperature, morphology), while a paragraph-level graph convolutional network (GCN) module resolves cross-sentence co-references. Rule-based templates enhance precision in specific cases. Extracted relations are integrated into a biomedical materials knowledge graph, enabling scalable and extensible data representation. Experiments show that the sentence-level model achieves 84.7% accuracy and the GCN-based module achieves 84.0%. This approach offers an efficient pipeline for structuring complex scientific texts, reducing manual effort and supporting large-scale knowledge extraction in biomedical materials and related domains.

Regenerative BiomaterialsVol. 12
Sichuan University (CN)
Sichuan University, National Science and Technology Major Project
Openalex Percentile: Top 81%
Biomedical Text Mining and Ontologies
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.