Bivariate-gated DNA nanoreactors for high-fidelity amplified imaging of tumor cells
Here, we report a bivariate-gated DNA nanoreactor enabling high-fidelity tumor cell imaging <i>via</i> amplified miRNA-21 detection. Endogenous apurinic/apyrimidinic endonuclease 1 (APE1) activates toehold unlocking to prevent leakage, while spatial confinement excludes pre-miRNA interference. This strategy distinguishes cancer cells from normal cells with minimal false positives, enabling reliable cancer diagnostics.
Authors
- Zhihe Qing (ORCID: https://orcid.org/0000-0002-6268-225X)
- Xueying Qiu
- Jing Tang (ORCID: https://orcid.org/0000-0002-6351-993X)
- Ke Quan
- Jiye Shi (ORCID: https://orcid.org/0000-0002-9628-8680)
- Kai Chen (ORCID: https://orcid.org/0000-0002-5395-3847)
- Ming Jin (ORCID: https://orcid.org/0000-0002-8446-1861)
Institutions
- Changsha University of Science and Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03986j
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- State Key Laboratory of Chemo/Biosensing and Chemometrics