Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer <i>via</i> epidermal growth factor receptor/extracellular signal-regulated kinase pathway
IL-22 promotes tumor growth and induces chemotherapy resistance in CRC cells by activating the EGFR/ERK signaling pathway. These findings suggest that targeting IL-22 or its downstream signaling may offer novel therapeutic strategies in CRC.
Authors
- Hang Ruan (ORCID: https://orcid.org/0000-0001-7506-3805)
- Lin Lin (ORCID: https://orcid.org/0000-0003-3397-6002)
- Xue Qin (ORCID: https://orcid.org/0000-0002-4513-3515)
- Yuanzhang Fang (ORCID: https://orcid.org/0000-0002-6985-9388)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i8.108535
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05