Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca<sup>2+</sup> pathway
DCA activates the Ca<sup>2+</sup>-CaMKII pathway, leading to ROS-mediated apoptosis in CRC cells, providing insights for potential therapeutic targets.
Authors
- Yizhang Wu (ORCID: https://orcid.org/0000-0001-6244-8458)
- Jiayan Chen (ORCID: https://orcid.org/0000-0002-8209-7218)
- Yongliang Lou (ORCID: https://orcid.org/0000-0003-4198-0001)
- Liqin Lou
- Li Yan (ORCID: https://orcid.org/0000-0002-4792-9998)
- Jie Lin (ORCID: https://orcid.org/0000-0002-5952-2319)
- Xiang Li (ORCID: https://orcid.org/0000-0003-1184-9635)
- Zhigui Zuo
- Jingyi Wen
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Lanzhou City University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i8.107453
- Citations
- 4
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 3.22