Mesenchymal stem cell-derived lncRNAs NKILA contributes to stemness and chemoresistance by fatty acid oxidation in gastric cancer <i>via</i> miR-485-5p/STAT3
MSCs enhance the stemness and chemoresistance of GC cells by secreting lncRNA NKILA, which promotes fatty acid oxidation through STAT3 activation. NKILA modulates the miR-485-5p/STAT3 axis, thereby increasing energy metabolism and supporting cancer stem cell properties. Targeting NKILA or the miR-485-5p/STAT3 pathway offers potential therapeutic strategies to overcome chemoresistance in GC.
Authors
- Xuejun Jiang (ORCID: https://orcid.org/0000-0002-8670-3828)
- Xiaojuan Lyu
- Lin Zhou (ORCID: https://orcid.org/0000-0002-5834-6894)
- Dan Zheng (ORCID: https://orcid.org/0000-0001-9808-8298)
Institutions
- Central Hospital of Wuhan (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i8.105006
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00