Gene Expression Profiling and Pathway Analysis of the Effect of Dienogest on Ovarian Endometriosis: A Comparative Study
Comparison of the dienogest-treated and untreated groups before endometriotic ovarian cyst surgery revealed pathways related to immune system function, inflammatory response, cell signaling and adhesion, and metabolic regulation. These findings suggest that dienogest may play a role in controlling inflammation and immune regulation, potentially alleviating endometriosis-related symptoms and delaying recurrence. Although further studies are required for validation, our preliminary findings suggest that dienogest may contribute to delaying the progression from endometriosis to carcinoma.
Authors
- Yun Soo Chung (ORCID: https://orcid.org/0000-0001-9168-0408)
- Heeyon Kim (ORCID: https://orcid.org/0000-0002-3128-8815)
- Seok Kyo Seo (ORCID: https://orcid.org/0000-0003-3404-0484)
- Jin Kyung Baek (ORCID: https://orcid.org/0000-0002-7958-0436)
- Jung Eun Shim (ORCID: https://orcid.org/0000-0001-6341-9923)
- Bo Hyon Yun (ORCID: https://orcid.org/0000-0001-5703-797X)
- Euna Choi (ORCID: https://orcid.org/0000-0002-2920-4037)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
Publication Details
- Journal
- Yonsei Medical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3349/ymj.2024.0518
- Citations
- 2
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea