Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a
These findings underscore the therapeutic potential of EGCG in OA management via antioxidative, anti-inflammatory properties, and Pla2g2a-mediated modulation. Notably, the consistency across <i>in vitro</i>, <i>in vivo,</i> and transcriptomic data supports the biological relevance of EGCG's effects, despite its PAINS characteristics.
Authors
- Sha Wan
- Jiaojiao Shang (ORCID: https://orcid.org/0000-0003-2110-7299)
- Qingquan Kong (ORCID: https://orcid.org/0000-0002-4732-4948)
- Mengyuan Dai
- Fan Chen (ORCID: https://orcid.org/0000-0003-4482-3116)
- Siyu Wang (ORCID: https://orcid.org/0000-0002-3791-3095)
- Tao Wang (ORCID: https://orcid.org/0000-0002-3475-6354)
- Jing Shi (ORCID: https://orcid.org/0009-0001-8779-7539)
- Siyuan Chen (ORCID: https://orcid.org/0000-0003-0061-8591)
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Fourth People's Hospital of Sichuan Province (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fphar.2025.1624818
- Citations
- 2
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Fundamental Research Funds for the Central Universities
- Science and Technology Plan Projects of Tibet Autonomous Region