Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring
Prenatal VPA exposure induces gut microbiota remodeling that exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis. This study provides evidence for linkages between taxonomic and metabolic gut dysbiosis and ASD-like pathophysiology, underscoring the therapeutic potential of microbiota-targeted interventions for neurodevelopmental disorders.
Authors
- Muhammad Majid (ORCID: https://orcid.org/0000-0002-9353-361X)
- Caixia Wu
- Zheng Sun (ORCID: https://orcid.org/0000-0003-2690-8327)
- Rajesh Basnet (ORCID: https://orcid.org/0000-0002-0128-8590)
- Zuoxian Lin
- Zhaoming Liu (ORCID: https://orcid.org/0000-0001-9146-4502)
- Nouman Amjad
- Yirong Sun (ORCID: https://orcid.org/0009-0006-8445-2814)
- Zhiyuan Li (ORCID: https://orcid.org/0000-0003-3435-4002)
Institutions
- Central South University (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Guangdong Academy of Sciences (CN)
- The Medical Device (United Kingdom) (GB)
- Xiangya Hospital Central South University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1633680
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22