Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia
Collectively, this study reveals the significance of iron overload in remodeling hematopoietic ecosystem and affecting HSC and LAM function in AML, providing new insights into the multifaceted role of iron overload in leukemia.
Authors
- Xuezhong Zhang (ORCID: https://orcid.org/0000-0002-7159-4702)
- Hao Wang (ORCID: https://orcid.org/0000-0003-2169-1712)
- Feifei Yang (ORCID: https://orcid.org/0000-0001-9362-7635)
- Guoguang Zheng (ORCID: https://orcid.org/0000-0002-0829-3501)
- Xiuqun Zhang
- Dongyue Zhang (ORCID: https://orcid.org/0000-0002-0697-4813)
- Yifei Li (ORCID: https://orcid.org/0000-0002-3096-4287)
- Lina Wang (ORCID: https://orcid.org/0009-0002-8518-8032)
- Dan Yang
- Wanzhen Xie
- Shulin Luo (ORCID: https://orcid.org/0009-0005-4643-2532)
- Xiaoxi Cui
Institutions
- Tianjin University of Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1626888
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau