Development and validation of a nomogram prediction model for factors influencing 131I-refractory Graves’ hyperthyroidism
This study found that the duration of GD hyperthyroidism, nighttime sleep quality, GO, effective half-life of thyroid <sup>131</sup>I, thyroid uptake <sup>99m</sup>Tc value, and thyroid mass are independent influencing factors of <sup>131</sup>I refractoriness. A risk prediction model including these six factors was established. This model provides guidance for the diagnosis and treatment decisions of <sup>131</sup>I refractory GD hyperthyroidism, offers a quantitative tool for clinical assessment of <sup>131</sup>I efficacy, and aids in personalized treatment decisions, reducing the burden of ineffective or inefficient treatments.
Authors
- Kehua Liao
- Dan Meng (ORCID: https://orcid.org/0000-0001-8588-0235)
- Shaobo Mo (ORCID: https://orcid.org/0000-0002-7400-9636)
- Fahuan Song (ORCID: https://orcid.org/0000-0002-4110-5912)
- Wentan Huang
- Lu Lu (ORCID: https://orcid.org/0000-0002-9330-7022)
- Zeyong Sun
- Xiaojuan Wei
- Yan Chen (ORCID: https://orcid.org/0000-0002-5317-1909)
Institutions
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fendo.2025.1628226
- Citations
- 1
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29