Recurrence and influencing factors of moderate-to-severe atopic dermatitis after dupilumab withdrawal: a retrospective cohort analysis
The cumulative recurrence rate in 141 AD patients was 23.4%; the median time to recurrence in 33 AD recurrence patients was 29 weeks (22-59 weeks); comorbid allergic conjunctivitis, treatment duration shorter than 16 weeks, obesity, male patients, and positive familial predisposition to allergy were independent risk factors for AD recurrence. These findings confirm the disease characteristic of AD's susceptibility to relapse and emphasize the need for individualized treatment, post-discontinuation monitoring, and long-term standardized management of AD patients with different risk factors for relapse.
Authors
- Lixia Zhang (ORCID: https://orcid.org/0009-0006-0122-5932)
- Xinyu Wen (ORCID: https://orcid.org/0000-0001-5160-6895)
- Qingqing Li (ORCID: https://orcid.org/0000-0002-1750-4681)
- Zhiyuan Jiang
- Zhen Cai (ORCID: https://orcid.org/0000-0002-8364-3954)
- Jie Liu (ORCID: https://orcid.org/0000-0001-6738-4801)
- Xinjie Zhang (ORCID: https://orcid.org/0009-0006-0476-1933)
- Maohua Chen
- Ge Yang (ORCID: https://orcid.org/0000-0003-3191-3083)
Institutions
- University of Electronic Science and Technology of China (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fmed.2025.1585368
- Citations
- 5
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- Department of Science and Technology of Sichuan Province