Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III
This is the first report that RM-1 acts as a novel DENV attachment inhibitor by targeting ED III. These findings show RM-1's promise as an anti-dengue therapeutic, supporting traditional herbs as sources of antivirals for flavivirus drug development.
Authors
- Lingzhu Shi
- Yuanru Zheng
- Chunyang Tian (ORCID: https://orcid.org/0000-0003-0466-8668)
- Jianhai Yu (ORCID: https://orcid.org/0000-0002-2986-8028)
- Daolin Tang (ORCID: https://orcid.org/0000-0002-1903-6180)
- Lijun Yan (ORCID: https://orcid.org/0009-0005-4740-0487)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-2422-8398)
- Huihui Cao
- Xuemei He
- Junshan Liu (ORCID: https://orcid.org/0000-0002-9326-6312)
- Haiyan Tian
- Zibin Lu (ORCID: https://orcid.org/0000-0001-7174-9420)
- Linzhong Yu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1663878
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00